University of Maryland Medical Center 1 article published in JoVE Medicine Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies Adeel Kaiser1, John G. Eley1, Nasarachi E. Onyeuku1, Stephanie R. Rice1, Carleen C. Wright2, Nathan E. McGovern2, Megan Sank2, Mingyao Zhu1, Zeljko Vujaskovic1, Charles B. Simone 2nd1, Arif Hussain3 1Department of Radiation Oncology, University of Maryland School of Medicine, 2Department of Radiation Oncology, University of Maryland Medical Center, 3Department of Medicine, University of Maryland School of Medicine, University of Maryland Greenebaum Comprehensive Cancer Center The fundamentals of radiation planning and delivery for proton therapy using prostate cancer as a model are presented. The application of these principles to other selected disease sites highlights how proton radiotherapy may enhance clinical outcomes for cancer patients.