University of Southern Mississippi 1 article published in JoVE Biochemistry A Polyaniline-based Sensor of Nucleic Acids Partha Pratim Sengupta1, Jared N. Gloria1, Marcus K. Parker1, Alex S. Flynt1 1Department of Biological Sciences, University of Southern Mississippi Nucleic acids are common analytes for assessing biological systems; however, bias from enzymatic manipulation can cause concern. Here a method is described for label-free detection of nucleic acids using polyaniline. This sensitive, cost-effective sensor technology can distinguish single nucleotide differences between molecules.