Pfizer Inc. 1 article published in JoVE Biology Application of Ultrasound and Shear Wave Elastography Imaging in a Rat Model of NAFLD/NASH Jeffrey Morin*1, Terri A. Swanson*2, Anthony Rinaldi3, Magalie Boucher4, Trenton Ross3, Dinesh Hirenallur-Shanthappa1 1Comparative Medicine, Pfizer Inc., 2Digital Medicine & Translational Imaging, Pfizer Inc., 3Internal Medicine Research Unit, Pfizer Inc., 4Drug Safety Research & Development, Pfizer Inc. This protocol describes the use of an enhanced ultrasound technique to non-invasively observe and quantify liver tissue changes in rodent models of nonalcoholic fatty liver disease.