Los Alamos National Laboratory View Institution's Website 3 articles published in JoVE Medicine Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults Luis Filipe Rocha Silva1, Bruna Caroline Chaves Garcia2, Zach A. Mang3, Fabiano Trigueiro Amorim4, Marco Fabrício Dias-Peixoto1, Fernando Gripp1, Valmor Tricoli5, Flávio de Castro Magalhães1,4 1Department of Physical Education, Federal University of the Jequitinhonha and Mucuri Valleys, 2Laboratory of Exercise Biology and Immunometabolism, Centro Integrado de Pós-Graduação e Pesquisa em Saúde, Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Federal University of the Jequitinhonha and Mucuri Valleys, 3Occupational Safety & Health, Los Alamos National Laboratory, 4Department of Health, Exercise, and Sports Sciences, University of New Mexico, 5School of Physical Education and Sport, University of Sao Paulo This study describes a randomized controlled trial protocol aiming at assessing the acute effects of strength exercise volume on insulin sensitivity in obese individuals. Chemistry Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles Saeed Mozaffari*1, Wenhui Li*1, Coogan Thompson1, Sergei Ivanov2, Soenke Seifert3, Byeongdu Lee4, Libor Kovarik5, Ayman M. Karim1 1Department of Chemical Engineering, Virginia Polytechnic Institute and State University, 2Center for Integrated Nanotechnologies, Los Alamos National Laboratory, 3Advanced Photon Source, Argonne National Laboratory, 4X-ray Science Division, Argonne National Laboratory, 5Environmental Molecular Science Laboratory, Pacific Northwest National Laboratory The main goal of this work is to elucidate the role of capping agents in regulating the size of palladium nanoparticles by combining in situ small angle x-ray scattering (SAXS) and ligand-based kinetic modeling. Biology Using Unfixed, Frozen Tissues to Study Natural Mucin Distribution Miriam Cohen1, Nissi M. Varki1, Mark D. Jankowski2, Pascal Gagneux1 1Department of Cellular and Molecular Medicine, University of California, San Diego, 2Biosecurity and Public Health, Los Alamos National Laboratory Unfixed frozen tissue samples embedded in Optimal Cutting Temperature medium (OCT) can be used to study natural distribution and glycosylation of secreted mucus. In this approach tissue processing is minimal and the natural presentation of glycolipids, mucins and glycan-epitopes is preserved. Tissue sections can be analyzed by immunohistochemistry using fluorescence or chromogenic detection.