9.7:
Pigmentation
Ever wonder why human skin comes in different colors? It turns out that skin color depends on the ratio of two melanin pigments, brown-black eumelanin and red-yellow pheomelanin.
Eumelanin is also extensively present in dark-colored hair, while pheomelanin is present mainly in blond and red-colored hair.
Both these melanin pigments are produced by melanocytes, the specialized cells present in the stratum basale of the epidermis.
In dark-skinned and brown-skinned people, melanocytes produce more melanin than in those with fair skin. Local accumulation of melanin is often seen as freckles and moles.
Prolonged exposure to sunlight often increases melanin production, which absorbs the harmful UV rays in the sunlight, transforming them into heat energy.
However, such a defensive response leads to skin darkening or tanning, often visible on fair skin.
Since people with fair skin produce less melanin, their skin epidermis—the outermost layer of the skin is almost transparent. So, the crimson-colored hemoglobin from the blood flowing in the underlying dermal capillaries renders a pinkish hue on the skin.
9.7:
Pigmentation
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale skin. Exposure to the UV rays of the sun or a tanning salon causes melanin to be manufactured and built up in keratinocytes, as sun exposure stimulates keratinocytes to secrete chemicals that stimulate melanocytes. The accumulation of melanin in keratinocytes results in the darkening of the skin or a tan. This increased melanin accumulation protects the DNA of epidermal cells from UV ray damage and the breakdown of folic acid, a nutrient necessary for our health and well-being. In contrast, too much melanin can interfere with the production of vitamin D, an important nutrient involved in calcium absorption.
It requires about ten days after initial sun exposure for melanin synthesis to peak, which is why pale-skinned individuals initially tend to suffer sunburns of the epidermis. Dark-skinned individuals can also get sunburns but are more protected than pale-skinned individuals. Melanosomes are temporary structures that are eventually destroyed by fusion with lysosomes; this fact, along with melanin-filled keratinocytes in the stratum corneum sloughing off, makes tanning impermanent.
Too much sun exposure can eventually lead to wrinkling due to the destruction of the cellular structure of the skin, and in severe cases, can cause sufficient DNA damage to result in skin cancer. When there is an irregular accumulation of melanocytes in the skin, freckles appear. Moles are large masses of melanocytes, and although most are benign, they should be monitored for changes that might indicate the presence of cancer.
This text is adapted from Openstax, Anatomy and Physiology 2e, Section 5.1: Layers of the Skin