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用于临床生产的正电子发射层析成像 (PET) 放射性同位素示踪合成协议的自动化
JoVE Journal
Chimica
This content is Free Access.
JoVE Journal Chimica
Automation of a Positron-emission Tomography (PET) Radiotracer Synthesis Protocol for Clinical Production
DOI:

10:20 min

October 26, 2018

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Capitoli

  • 00:04Titolo
  • 00:53Synthesis Protocol Automation
  • 02:13Setup for Automated Synthesis
  • 05:25Automated Synthesis, Purification and Formulation, and Post-Run System Shutdown
  • 09:10Results: Representative Quality Control Test Data Summary for Three Validation Batches
  • 09:33Conclusion

Summary

Traduzione automatica

参与多个早期临床研究试验的正电子发射断层扫描 (PET) 成像站点需要强大且多才多艺的放射性同位素示踪制造能力。以放射性同位素示踪 [18F] 克罗拉滨为例, 说明如何使用灵活、基于磁带的 radiosynthesizer 自动合成放射性同位素示踪, 并验证临床使用的合成。

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