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低聚β-淀粉样蛋白的制备_1-42和突触可塑性损伤诱导海马脑片

JoVE Journal
Neuroscienze

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JoVE Journal Neuroscienze

Preparation of Oligomeric β-amyloid_1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

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低聚β-淀粉样蛋白的制备_1-42和突触可塑性损伤诱导海马脑片

DOI:

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04:41 min

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July 14, 2010

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Mauro Fa, Ian J. Orozco, Yitshak I. Francis, Faisal Saeed, Yimin Gong, Ottavio Arancio

¹Taub Institute for Research on Alzheimer’s Disease and Aging Brain,Columbia University

Capitoli

00:04Titolo
00:35Introduction
01:03Preparation of Oligomeric Beta-amyloid 1-42
03:03Hippocampal Slice Treatment & LTP Induction
04:04Conclusion

Summary

Traduzione automatica

阿尔茨海默氏病的一个特点是海拔的Aβ<sub> 1-42</sub>肽。在这里，我们提供的协议，为准备合成的Aβ<sub> 1-42</sub>低聚物，损害海马长时程增强，蜂窝关联的内存。此过程是有用的调查Aβ诱导的病理和药物筛选机制。

Tags

Oligomeric β-amyloid1-42 Induction Of Synaptic Plasticity Impairment Hippocampal Slices Alzheimer’s Disease Aβ Peptide Long-term Potentiation Learning And Memory Synaptic Dysfunctions Drug Screening Oligomerized Synthetic Aβ1-42 Peptide LTP Disruption Experimental Paradigm Control Experiment

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