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Journal / Neuroscience / Mouse Models of Periventricular Leukomalacia
JoVE Journal
Neuroscience

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JoVE Journal Neuroscience
Mouse Models of Periventricular Leukomalacia
 

Mouse Models of Periventricular Leukomalacia

Article DOI: 10.3791/1951-v • 06:24 min • May 18th, 2010
May 18th, 2010 •
1, 1, 1
1Department of Cell Biology and Human Anatomy Institute for Pediatric Regenerative Medicine School of, University of California, Davis

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Automatic Translation

We established mouse models of periventricular leukomalacia (PVL), the predominant brain injury in premature infants characterized by periventricular white matter lesions. Hypoxia/ischemia with/without systemic infection are the primary causes of PVL. Unilateral carotid ligation and hypoxia exposure with/without lipopolysaccharide injection creates PVL-like lesions in P6 mice.

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Mouse Models Periventricular Leukomalacia PVL Brain Injury Premature Infants Cerebral Palsy White Matter Damage Oligodendroglial Injury Hypoxia/ischemia Systemic Infection/inflammation P6 Mice Neonatal Brain Injury Carotid Ligation Endotoxin Lipopolysaccharide (LPS) Myelin Basic Protein (MBP) O1 Electron Microscopic Examination Hippocampus Thalamus Disease Pathogenesis Transgenic Mouse Strains Drug Trials Therapeutic Agents Stem Cell Transplantation Immunodeficiency Mouse Strains
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