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In Situ Mouse Liver Perfusion Model to Study Metabolic Responses to Substrates

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Leveroperatie en perfusie van muizen voor het bestuderen van het levermetabolisme

JoVE Journal
Medicina

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JoVE Journal Medicina

Mouse Liver Operation and Perfusion for Studying Hepatic Metabolism

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Leveroperatie en perfusie van muizen voor het bestuderen van het levermetabolisme

In Situ Mouse Liver Perfusion Model to Study Metabolic Responses to Substrates

DOI:

10.3791/200531-v

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04:47 min

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October 06, 2023

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Marie Winther-Sørensen^2,3, Ida Marie Kemp³, Hanne Cathrine Bisgaard, Jens Juul Holst⁵, Nicolai J. Wewer Albrechtsen³

¹Department of Biomedical Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, ²NNF Center for Protein Research, Faculty of Health and Medical Sciences,University of Copenhagen, ³Department for Clinical Biochemistry,Copenhagen University Hospital – Bispebjerg and Frederiksberg, ⁴Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences,University of Copenhagen, ⁵NNF Center for Basic Metabolic Research, Faculty of Health and Medical Sciences,University of Copenhagen

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Keywords: Mouse Liver Hepatic Metabolism Perfusion Abdominal Incision Portal Vein Suprahepatic Inferior Vena Cava Perfusion Flow Rate Pressure Recording Baseline Sample Collection Test Substance Infusion

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