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在自觉大鼠高胰岛素 - 正常血糖钳
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JoVE Journal Medicina
Hyperinsulinemic-Euglycemic Clamp in the Conscious Rat
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在自觉大鼠高胰岛素 - 正常血糖钳

DOI:
10.3791/2432-v

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11:12 min

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February 07, 2011

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, , ,
1Department of Biochemistry and Molecular Biology, Faculty of Medicine,University of Calgary, 2Faculty of Kinesiology,University of Calgary

Capitoli

  • 00:05Titolo
  • 00:38Introduction
  • 00:54Surgical Preparation
  • 02:07Surgery
  • 05:11Maintaining Catheter Patency
  • 07:14Hyperinsulinemic-Euglycemic Clamp
  • 09:54Representative Results
  • 10:51Conclusion

Summary

Traduzione automatica

Traduzione automatica

高胰岛素 - 正常血糖钳是胰岛素的作用进行评估的“金标准”。胰岛素是注入在一个恒定的刺激葡萄糖摄取率。注入外源性葡萄糖的量，以应对这一下降是胰岛素敏感性的指标。这里的程序是一种自觉的，奔放的大鼠上进行。

Tags

Hyperinsulinemic-euglycemic ClampType 2 DiabetesInsulin SensitivityBlood Glucose LevelsInsulin ProductionInsulin UtilizationGold-standardHyperinsulinemic-euglycemic Clamp ProcedureInfusion Of InsulinDrop In Blood GlucoseExogenous GlucoseVenous CirculationHomeostasisInsulin Sensitivity AssessmentChronically Catheterized RatAnesthesia InductionCarotid Artery CatheterizationJugular Vein CatheterizationHeparinized Saline FlushWeight Gain MonitoringFastingInsulin And D50 Infusion

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