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An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery
 

An in vivo Rodent Model of Contraction-induced Injury and Non-invasive Monitoring of Recovery

Article DOI: 10.3791/2782-v • 08:08 min • May 11th, 2011
May 11th, 2011 •
1,2, 1, 2, 2, 3
1Department of Physiology, University of Maryland School of Medicine, 2Department of Orthopaedics, University of Maryland School of Medicine, 3Department of Diagnostic Radiology, University of Maryland School of Medicine

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An in vivo animal model of injury is described. The method takes advantage of the subcutaneous position of the fibular nerve. Velocity, timing of muscle activation, and arc of motion are all pre-determined and synchronized using commercial software. Post injury changes are monitored in vivo using MR imaging/spectroscopy.

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In Vivo Rodent Model Contraction-induced Injury Non-invasive Monitoring Recovery Muscle Strains Muscle Injury Diagnosis Clinical Presentation Muscle Damage Assessment Biological Markers Serum Creatine Kinase Levels Loss Of Force Production Histological Findings Overall Health Of The Muscle Contractile Force Biomechanical Conditions In Vivo Animal Model Torque Measurement Reliable Muscle Injury Isolated Muscle Measurement Small Animal MRI Procedure
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