This content is Free Access.
Capitoli
- 00:05Titolo
- 01:18Fixation of Mouse Brains and Cryosectioning
- 02:14Immunohistochemistry Procedure for Neuritic Plaques
- 03:44Thioflavin S Staining Procedure for Detection of Neuritic Plaques
- 04:38Valproic Acid Inhibition of Neuritic Plaque Formation
One of the pathological characteristics of AD is the formation of Amyloid β protein positive neuritic plaques. In this protocol we describe two methods to detect neuritic plaques in transgenic AD model mice: immunohistochemical detection using the ABC and DAB method and fluorescent detection using thioflavin S staining method.
