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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

DOI:
10.3791/3154-v

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10:27 min

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December 15, 2011

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, , , , ,
1Division of Microbiology,Tulane National Primate Research Center, 2Division of Comparative Pathology,Tulane National Primate Research Center, 3Division of Veterinary Medicine,Tulane National Primate Research Center

Capitoli

  • 00:05Titolo
  • 01:46Skin Biopsy Sample Collection
  • 03:03Sample Processing, Staining and Evaluation
  • 06:47Skin Biopsy Staining
  • 09:35Conclusion

Summary

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Dermatitis herpetiformis (DH) is a chronic inflammatory condition characterized by an autoimmune reaction between IgA and epidermal transglutaminase (eTG). DH develops in a very small portion of gluten-sensitive and/or celiac patients. The results of this study indicate that DH can also develop in a rhesus monkey host with symptoms of idiopatic dermatitis.

Tags

Epidermal TransglutaminaseIgA AntibodiesRhesus DermatitisCeliac DiseaseAutoimmune ResponseSmall Intestinal WallGliadin PeptidesDermatitis HerpetiformisConfocal Microscopy ExaminationBiopsy SamplesRhesus Macaques

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