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Journal / Medicine / A Swine Model of Neonatal Asphyxia
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A Swine Model of Neonatal Asphyxia
 
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A Swine Model of Neonatal Asphyxia

Article DOI: 10.3791/3166-v • 10:36 min • October 11th, 2011
October 11th, 2011 •
1, 2, 2
1Departments of Pediatrics, Pharmacology and Surgery, University of Alberta, 2Department of Surgery, University of Alberta

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Large animal models have good translational values in the examination of physiology and pharmacology of neonatal asphyxia. Using newborn piglets, we develop an experimental protocol to simulate neonatal asphyxia which has advantages of studying the systemic and regional hemodynamics, oxygen transport with biochemical and pathologic pathways and correlations.

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Swine Model Neonatal Asphyxia Multi-organ Failure Hypotension Perfusion Deficit Hypoxic-ischemic Encephalopathy Pulmonary Hypertension Vasculopathic Enterocolitis Renal Failure Thrombo-embolic Complications Animal Models Patho-physiology Pharmacology Newborn Piglet Body Systems Hemodynamic Changes Interventions Multi-organ Failure Dysfunction Surgical Instrumentation Mechanical Ventilation Vascular
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