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Prediction of HIV-1 Coreceptor Usage (Tropism) by Sequence Analysis using a Genotypic Approach
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1Institute of Virology,University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology,University of Duesseldorf, 5Department of Dermatology,University of Essen, 6Department of Internal Medicine,University of Cologne, 7Augustinerinnen Hospital
Capitoli
- 00:05Titolo
- 02:02Amplification of the V3 Region
- 03:25Sequencing of the V3 Amplicon
- 04:08Sequencing Editing, Data Interpretation, and Trophism Prediction
- 06:31Conclusion
The prediction of the coreceptor usage of HIV-1 is required for the administration of a new class of antiretroviral drugs, i.e. coreceptor antagonists. It can be performed by sequence analysis of the env gene and subsequent interpretation through an internet based interpretation system (geno2pheno[coreceptor]).
