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Habituation and Prepulse Inhibition of Acoustic Startle in Rodents
JoVE Journal
Neuroscienze
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JoVE Journal Neuroscienze
Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

Habituation and Prepulse Inhibition of Acoustic Startle in Rodents

DOI:
10.3791/3446-v

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08:38 min

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September 01, 2011

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1Anatomy and Cell Biology, Schulich School of Medicine and Dentistry,University of Western Ontario

Capitoli

  • 00:05Titolo
  • 00:49Instrument Preparations
  • 01:24Animal Handling, Acclimation and Establishing an Input/Output Function
  • 02:52Measuring Habituation, Prepulse Inhibition (PPI), and Long-term Habituation (LTH)
  • 06:49Common I/O, Habituation, PPI, and LTH Measurements
  • 08:13Conclusion

Summary

Traduzione automatica

Traduzione automatica

Habituation and prepulse inhibition of startle are operational measures of sensory gating. Sensory gating is disrupted in schizophrenia, and some other mental disorders and neurodegenerative diseases. We here describe a standard protocol to assess short-term and long-term habituation as well as prepulse inhibition of acoustic startle responses in rats and mice.

Tags

Acoustic StartleHabituationPrepulse InhibitionRodentsProtective ResponseReflexive ResponseFear Potentiated StartleJoy Attenuated StartleNon-associative Learning ProcessesSensitizationSensory GatingEmotionsLearningSensory StimuliShort-term HabituationLong-term Habituation

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