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Immunology and Infection
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JoVE Journal Immunology and Infection
Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters
 

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Article DOI: 10.3791/3533-v • 11:36 min • April 21st, 2012
April 21st, 2012 •
1, 1,2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 1
1Program for the Study and Control of Tropical Diseases -PECET-School of Medicine, University of Antioquia, 2School of Agrarian Sciences, University of Antioquia

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Optimization of the experimental hamster model for cutaneous leishmaniasis by intradermal injection of Leishmania promastigotes at the dorsal skin. This approach is useful during inoculation, follow-up, characterization of lesions, application of treatments and obtaining of clinical samples. Locomotion, search for food and water, play and social activities are preserved.

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Cutaneous Leishmaniasis Dorsal Skin Hamsters Screening Antileishmanial Drugs Inoculation Ulcer Lesion Size Measurement Hamster Model Optimization Golden Hamsters Intradermal Injection Promastigotes Leishmania Species Progression Of Lesions Infection Evaluation Chronic Lesions Clinical Evolution Indurations Ulcers Treatment Application Clinical Samples
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