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临床试验和脊髓去除在肌萎缩性侧索硬化症的小鼠模型（ALS）
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Medicina
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JoVE Journal Medicina
Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)
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临床试验和脊髓去除在肌萎缩性侧索硬化症的小鼠模型（ALS）

DOI:
10.3791/3936-v

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12:35 min

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March 17, 2012

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, , , , ,
1Dept. of Neurology,University Medicine Göttingen, 2DFG Research Center for the Molecular Physiology of the Brain (CMPB),Göttingen, Germany

Capitoli

  • 00:02Titolo
  • 01:07Clinical Testing of the SOD G93A Mouse Model of ALS
  • 02:03Hanging Wire Test
  • 03:05Rotarod Test
  • 04:30Spinal Cord Preparation
  • 10:55Spinal Cord Immunohistochemistry
  • 11:41Conclusions

Summary

Traduzione automatica

Traduzione automatica

一个肌萎缩性侧索硬化症（ALS）的小鼠模型研究，临床和行为。作为一个伴随的免疫组织化学分析的前提下编制的脊髓详细描述。

Tags

Clinical TestingSpinal Cord RemovalMouse ModelAmyotrophic Lateral SclerosisALSNeurodegenerative DisorderMotoneuronsFamilial MutationsSOD GeneSOD1 (G93A) MutationOverall SurvivalClinical CourseMotor FunctionBehavioural Motor TestsQuantitative Scoring SystemsImmunohistochemical ExaminationSpinal Cord PreparationDorsal Laminectomy MethodHistological FindingsTherapeutic OptionsHuman Clinical Trials

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