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Viral Nanoparticles for In vivo Tumor Imaging
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JoVE Journal Bioingegneria
Viral Nanoparticles for In vivo Tumor Imaging

Viral Nanoparticles for In vivo Tumor Imaging

DOI:
10.3791/4352-v

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14:04 min

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November 16, 2012

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, , , , ,
1Department of Biomedical Engineering,Case Western Reserve University , 2Department of Biomedical Engineering, Radiology, and Materials Science and Engineering,Case Western Reserve University

Capitoli

  • 00:05Titolo
  • 03:04Viral Nanoparticle Propagation
  • 04:00VNP Purification
  • 05:43Chemical Conjugation of VNPs and VNP Characterization
  • 07:49Tumor-targeting In Vivo
  • 09:00Results: Plant Viral Nanoparticles for In Vivo Tumor Imaging
  • 13:01Conclusion

Summary

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Plant viral nanoparticles (VNPs) are promising platforms for applications in biomedicine. Here, we describe the procedures for plant VNP propagation, purification, characterization, and bioconjugation. Finally, we show the application of VNPs for tumor homing and imaging using a mouse xenograft model and fluorescence imaging.

Tags

NanoparticlesIn Vivo Tumor ImagingNanomaterialsMaterials ScienceMedicinaViral Nanoparticles (VNPs)Plant VirusesCowpea Mosaic Virus (CPMV)Brome Mosaic Virus (BMV)Tobacco Mosaic Virus (TMV)Potato Virus X (PVX)Monodisperse ParticlesLarge-scale ProductionStabilityBiocompatibilityGenetic ModificationChemical Bioconjugation MethodsAtomic Resolution

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