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JoVE Journal Neuroscience
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
 

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Article DOI: 10.3791/4411-v • 10:59 min • November 19th, 2012
November 19th, 2012 •
1,2, 1, 1, 1, 1, 1,3
1Division of Neurology, Children's Hospital of Philadelphia, 2Neuroscience Graduate Group, Perelman School of Medicine at the University of Pennsylvania, 3Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania

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A multi-faceted approach to investigating functional changes to hippocampal circuitry is explained. Electrophysiological techniques are described along with the injury protocol, behavioral testing and regional dissection method. The combination of these techniques can be applied in similar fashion for other brain regions and scientific questions.

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Investigations Alterations Hippocampal Circuit Function Mild Traumatic Brain Injury TBI Neurological Impairments Memory Deficits Seizure Threshold Hippocampal Dysfunction Lateral Fluid Percussion Injury Animal Model Neuronal Cell Loss Gliosis Ionic Perturbation Combinatorial Method Ex Vivo Physiological Techniques Animal Behavior Analysis Biochemical Analysis Cognitive Disability Extracellular Field Potential Recording Whole-cell Patch-clamping Voltage Sensitive Dye Recording Regionally Dissecting Subregions Of The Hippocampus Neurochemical Analysis Metabolic Analysis
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