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清醒小鼠滴鼻的CNS药物治疗管理
JoVE Journal
Medicina
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JoVE Journal Medicina
Intranasal Administration of CNS Therapeutics to Awake Mice
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清醒小鼠滴鼻的CNS药物治疗管理

DOI:
10.3791/4440-v

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07:15 min

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April 08, 2013

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, , ,
1Alzheimer’s Research Center at Region’s Hospital,HealthPartners Institute for Education and Research

Capitoli

  • 00:05Titolo
  • 01:20Acclimation to Handling for Intranasal Dosing to Awake Mice
  • 04:15Intranasal Delivery of Drug to Awake Mice
  • 05:57General Animal Handling Techniques for Acclimation and Intranasal Delivery of Drug to Awake Mice
  • 06:34Conclusion

Summary

Traduzione automatica

Traduzione automatica

目的针对脑清醒小鼠鼻内给药的方法，进行说明。这种方法允许重复给药，长期使用鼻腔给药的药物无需麻醉，并以最小的全身暴露的鼻子到大脑传递。

Tags

Intranasal AdministrationCNS TherapeuticsAwake MiceNon-invasive DeliveryBlood-brain BarrierTargeted Drug DeliverySystemic ExposureIntranasal Delivery In Clinical TrialsPharmacokinetic DistributionEfficacy EvaluationAwake Delivery In MiceChronic Dosing Without AnesthesiaIntranasal Grip For Mice

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