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Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique
 

Evaluation of Respiratory System Mechanics in Mice using the Forced Oscillation Technique

Article DOI: 10.3791/50172-v • 13:10 min • May 15th, 2013
May 15th, 2013 •
*1, *2, 2, 2, 1
1Meakins-Christie Laboratories, Department of Medicine, McGill University, 2SCIREQ Scientific Respiratory Equipment Inc.
* These authors contributed equally

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The present protocol provides a detailed step-by-step description of the procedures required to execute measurements of respiratory system mechanics as well as the assessment of airway responsiveness to inhaled methacholine in mice using the forced oscillation technique (flexiVent; SCIREQ Inc, Montreal, Qc, Canada).

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Forced Oscillation Technique FOT Respiratory System Mechanics Mice Lung Function Pressure And Volume Signals Airflow Waveforms Computer-controlled Piston Ventilator FlexiVent Preparatory Steps Mechanical Ventilation Lung Function Measurements Data Analysis Airway Responsiveness Methacholine Anesthetized Mice Oxidative-stress Driven Model Airway Damage Physiological Changes Disease Models Research Areas
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