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Bioengineering

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JoVE Journal Bioengineering
Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing
 

Generation of Aligned Functional Myocardial Tissue Through Microcontact Printing

Article DOI: 10.3791/50288-v • 11:09 min • March 19th, 2013
March 19th, 2013 •
1, 1,2
1Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, 2Harvard Stem Cell Institute

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Automatic Translation

The generation of aligned myocardial tissue is a key requirement for adapting the recent advances in stem cell biology to clinically useful purposes. Herein we describe a microcontact printing approach for the precise control of cell shape and function. Using highly purified populations of embryonic stem cell derived cardiac progenitors, we then generate anisotropic functional myocardial tissue.

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Keywords: Microcontact Printing Cardiac Tissue Engineering Stem Cell-derived Cardiomyocytes Heart Failure Functional Myocardial Tissue Extracellular Matrix Cell Alignment Anisotropic Tissue
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