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5/6th联合切除术，高盐饮食和一氧化氮合酶抑制剂诱导Lewis大鼠慢性肾脏病
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JoVE Journal Medicina
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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5/6th联合切除术，高盐饮食和一氧化氮合酶抑制剂诱导Lewis大鼠慢性肾脏病

DOI:
10.3791/50398-v

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08:50 min

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July 03, 2013

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, , ,
1Department of Nephrology & Hypertension,University Medical Center Utrecht

Capitoli

  • 00:05Titolo
  • 01:15Preparation for Surgery
  • 05:13Left Side Subtotal Nephrectomy
  • 06:12Representative Nephrectomy Results
  • 08:23Conclusion

Summary

Traduzione automatica

Traduzione automatica

两阶段方法建立Lewis大鼠慢性肾脏病（CKD），通过手术取出肾质量5/6th描述。结合的外科手术过程中，一氧化氮合酶抑制和高盐饮食导致类似人类的CKD的模型，允许因果机制的研究和发展新的治疗干预。

Tags

5/6th NephrectomyChronic Kidney DiseaseLewis RatHigh Salt DietNitric Oxide Synthase InhibitionGlomerular Filtration RateRenal Plasma FlowHypertensionProteinuriaUremiaTubulo-interstitial DamageGlomerulosclerosis

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