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Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
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JoVE Journal Medicina
Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

DOI:
10.3791/50865-v

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09:43 min

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January 14, 2014

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, , ,
1Department of Neurology,Vanderbilt University Medical Center, 2Vanderbilt Ingram Cancer Center,Vanderbilt University Medical Center, 3Neurology Service,Veteran Affairs TVHS

Capitoli

  • 00:05Titolo
  • 01:49Preparation of Tumor Cell Suspension
  • 04:41Intracranial Transplantation
  • 06:22Tumor Harvesting
  • 07:25Results: Tumor Growth after Grafting
  • 09:15Conclusion

Summary

Traduzione automatica

Traduzione automatica

Malignant gliomas constitute a heterogeneous group of highly infiltrative glial neoplasms with distinct clinical and molecular features. Primary orthotopic xenografts recapitulate the histopathological and molecular features of malignant glioma subtypes in preclinical animal models.

Tags

GliomaXenograftOrthotopicInfiltrative GrowthIsocitrate DehydrogenaseMalignant GliomaWHO Grade IIIWHO Grade IVPrimary XenograftTumor TransplantationImmunocompromised MiceTumor DissociationSurgical Procedure

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