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Analysis of Skeletal Muscle Defects in Larval Zebrafish by Birefringence and Touch-evoke Escape Response Assays
JoVE Journal
Biologia
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JoVE Journal Biologia
Analysis of Skeletal Muscle Defects in Larval Zebrafish by Birefringence and Touch-evoke Escape Response Assays
DOI:

08:01 min

December 13, 2013

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Capitoli

  • 00:05Titolo
  • 01:44In vivo Analysis of Skeletal Muscle Structure by Birefringence
  • 04:23Touch-evoked Escape Behavior Assay
  • 05:10Results: Representative WT and Mutant Skeletal Muscle Analyses
  • 07:28Conclusion

Summary

Traduzione automatica

The zebrafish is now an established and powerful tool for modeling muscular dystrophies, congenital myopathies, and related neuromuscular diseases. Birefringence and touch-evoked escape behavior are two common noninvasive assays used to determine the degree of muscular disorganization and locomotive impairment of zebrafish embryos during early development.

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