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Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
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Capitoli
- 00:05Titolo
- 02:05Organic Electrochemical Transistor Fabrication
- 04:46Device Assembly
- 05:35Cell Culture
- 06:20Measurements with OECT and Cell Integration
- 07:50Preparatin and Introduction of Toxic Compound
- 08:39Results: Sensing of Barrier Tissue Disruption with and OECT
- 10:31Conclusion
The Organic Electrochemical Transistor is integrated with live cells and used to monitor ion flux across the gastrointestinal epithelial barrier. In this study, an increase in ion flux, related to disruption of tight junctions, induced by the presence of the calcium chelator EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetra acetic acid), is measured.
