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Indledning af metastatisk brystkræft karcinom ved Målretning af Duktalt epitel med Adenovirus-Cre: A Novel transgene mus Model for brystkræft
JoVE Journal
Medicina
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JoVE Journal Medicina
Initiation of Metastatic Breast Carcinoma by Targeting of the Ductal Epithelium with Adenovirus-Cre: A Novel Transgenic Mouse Model of Breast Cancer

Indledning af metastatisk brystkræft karcinom ved Målretning af Duktalt epitel med Adenovirus-Cre: A Novel transgene mus Model for brystkræft

DOI:
10.3791/51171-v

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07:13 min

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March 26, 2014

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, , , , , , , , , ,
1Tumor Microenvironment and Metastasis Program,Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine,University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics,Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine,University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center,University of Pennsylvania, 6Center for Advanced Medicine,University of Pennsylvania

Capitoli

  • 00:05Titolo
  • 01:13Intraductal Injection of Virus Particles
  • 04:00Results: Representative Tumor Formation and Metastasis
  • 06:35Conclusion

Summary

Traduzione automatica

Traduzione automatica

Aktivering af latente mutationer med adenovirus-Cre i brystkirtler duktalt system resulterer i en klinisk relevant metastatisk brystkræft. Indarbejdelse af en YFP promotor muliggør sporing af distale metastatiske tumorceller. Denne model er nyttig til at studere latent metastase, anti-tumor immunitet og for at udforme nye immunoterapier til behandling af brystkræft.

Tags

Metastatic Breast CarcinomaTransgenic Mouse ModelDuctal EpitheliumAdenovirus-creP53 AblationK-ras OncogeneTumor ProgressionLymphovascular InvasionLeukocyte InfiltrationLatent MetastasisDormancyImmunotherapy

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