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1Tumor Microenvironment and Metastasis Program,Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine,University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics,Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine,University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center,University of Pennsylvania, 6Center for Advanced Medicine,University of Pennsylvania
Capitoli
- 00:05Titolo
- 01:13Intraductal Injection of Virus Particles
- 04:00Results: Representative Tumor Formation and Metastasis
- 06:35Conclusion
Aktivering av latent mutasjoner med adenovirus-Cre i melke ductal systemet resulterer i en klinisk relevant metastatisk brystkreft. Inkorporering av en YFP promoter tillater sporing av distale metastatiske tumorceller. Denne modellen er nyttig for å studere latent metastase, anti-tumor immunforsvar, og for å utforme nye immunterapi for å behandle brystkreft.
