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1Division of Hematology-Oncology, Department of Internal Medicine,University of Cincinnati College of Medicine, 2Division of Human Genetics,University of Cincinnati College of Medicine, 3Department of Radiology,University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children’s Hospital Medical Center,University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center,The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center,The Ohio State University Medical Center
Capitoli
- 00:05Titolo
- 01:25Preparation of Animal Models and Fluorescently-labeled SapC-DOPS Nanovesicles
- 03:27Fluorescence Imaging
- 05:30Results: Optical Imaging of Brain Tumors and Arthritis in SapC-DOPS Nanovesicle Injected Mice
- 08:35Conculsion
Vi beskriver en multi-vinkel roterande optisk avbildning (Maroi) systemet för in vivo kvantifiering av en fluorescerande markör levereras av saposin C (SAPC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Under användning musmodeller av cancer och artrit, visar vi hur signalkurvan analysen Maroi kan användas för noggrann kartläggning och biologisk karakterisering av sjukdomsprocesser.
