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Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle’s Mapping and Quantification in Organ Tissue
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Capitoli
- 00:05Titolo
- 02:45Biological Sample Preparation and Calibration Sample Preparation
- 04:03The Laser Induced Breakdown Spectroscopy (LIBS) Setup
- 05:56Mapping Measurement and Calibration Measurement
- 07:16Results: LIBS Spectra and Chemical Maps of Mouse Tissue
- 09:02Conclusion
Laser-induced breakdown spectroscopy performed on thin organ and tumor tissue successfully detected natural elements and artificially injected gadolinium (Gd), issued from Gd-based nanoparticles. Images of chemical elements reached a resolution of 100 μm and quantitative sub-mM sensitivity. The compatibility of the setup with standard optical microscopy emphasizes its potential to provide multiple images of a same biological tissue.
