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制造浓缩，脂质为基础的氧气微泡的乳液由高剪切均质化和串行集中
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Bioingegneria
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JoVE Journal Bioingegneria
Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
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制造浓缩，脂质为基础的氧气微泡的乳液由高剪切均质化和串行集中

DOI:
10.3791/51467-v

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13:17 min

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May 26, 2014

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, , ,
1Department of Cardiology, Boston Children’s Hospital,Harvard Medical School, 2Department of Anesthesiology and Critical Care, Children’s Hospital of Philadelphia,University of Pennsylvania

Capitoli

  • 00:05Titolo
  • 01:54System Set-up
  • 04:23LOM Manufacture
  • 07:33Collection, Concentration, Assessment, and Storage of LOMs
  • 10:19Results: LOMs Can Be Manufactured in High Capacity and with High Oxygen Purity by High Shear Homogenization and Serial Concentration
  • 12:39Conclusion

Summary

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我们描述了大容量的基于脂质的氧气微气泡（的LOM），使用高剪切均化和串行浓度设计用于静脉内的氧气输送的制造方法。

Tags

Lipid-based Oxygen MicrobubblesHigh Shear HomogenizationConcentrationUltrasound Contrast AgentsDrug DeliveryGas-filled MicrobubblesSurfactantsHomogenizationOxygen DeliveryHypoxemiaOrgan InjuryCardiac Arrest

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