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Construction and Characterization of a Novel Vocal Fold Bioreactor
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JoVE Journal Bioingegneria
Construction and Characterization of a Novel Vocal Fold Bioreactor

Construction and Characterization of a Novel Vocal Fold Bioreactor

DOI:
10.3791/51594-v

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11:11 min

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August 01, 2014

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, , ,
1Biomedical Engineering Program,University of Delaware, 2Department of Materials Science and Engineering, Delaware Biotechnology Institute,University of Delaware

Capitoli

  • 00:05Titolo
  • 01:15Scaffold Fabrication
  • 02:58Bioreactor Assembly
  • 05:34Bioreactor Characterization
  • 07:00Vibratory Cell Culture
  • 08:44Results: Vibration Induces Extra Cellular Matrix (ECM) Protein Expression in MSC Cultures
  • 10:44Conclusion

Summary

Traduzione automatica

Traduzione automatica

A novel vocal fold bioreactor capable of delivering physiologically relevant, vibratory stimulation to cultured cells is constructed and characterized. This dynamic culture device, when combined with a fibrous poly(ε-caprolactone) scaffold, creates a vocal fold-mimetic environment that modulates the behaviors of mesenchymal stem cells.

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Keywords: Vocal Fold BioreactorVibration StimulationMechanotransductionExtracellular MatrixMesenchymal Stem Cells

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