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Bioengineering

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JoVE Journal Bioengineering
The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits
 

The Use of the Ex Vivo Chandler Loop Apparatus to Assess the Biocompatibility of Modified Polymeric Blood Conduits

Article DOI: 10.3791/51871-v • 10:15 min • August 20th, 2014
August 20th, 2014 •
1,2, 1,2, 1,2, 1,2
1Division of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, 2University of Pennsylvania Perelman School of Medicine

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Blood exposure to polymeric blood conduits initiates the foreign body reaction that has been implicated in clinical complications. Here, the Chandler Loop Apparatus, an experimental tool mimicking blood perfusion through these conduits, is described. Appendage of recombinant CD47 results in decreased evidence of the foreign body reaction on these conduits.

Tags

Ex Vivo Chandler Loop Apparatus Biocompatibility Modified Polymeric Blood Conduits Foreign Body Reaction Blood Proteins Platelets Monocyte/macrophage Adhesion Inflammatory Cell Signaling Events Post-procedural Complications Molecular Interactions Cellular Interactions Large Volumes Of Blood Perfusion Polymeric Conduits Ex Vivo Model Anti-inflammatory Properties Polymer Surface Modifications Photoactivation Chemistry Recombinant CD47 Biocompatibility Promotion Efficacy Promotion Photoactivation Chemistry Methodology
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