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1Department of Pathology,Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program,Memorial Sloan Kettering Cancer Center, 3Department of Radiology,Weill Cornell Medical College, 4Department of Medicine,Memorial Sloan Kettering Cancer Center, 5Department of Oncology,Memorial Sloan Kettering Cancer Center, 6Department of Surgery,Memorial Sloan Kettering Cancer Center
Capitoli
- 00:05Titolo
- 02:30Tissue Procurement
- 04:09Preparation of Materials for Sectioning and Vibratome Settings
- 05:19Tissue Sectioning, Treatment, and Analyses
- 06:25Results: Ex Vivo Metastatic Breast Cancer Response to Heat Shock Protein 90 Inhibitor
- 07:56Conclusion
Etablerede cancer cellelinjer og xenografter har været grundpillen i kræftforskning i de sidste mange årtier. Seneste oplysninger tyder dog på, at terapeutiske reaktion i høj grad er påvirket af tumorcellens mikromiljø. Derfor har vi udviklet en ex vivo analyse af primær tumor prøver for lægemiddeludvikling formål.
