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Mouse Kidney Transplantation
 

Mouse Kidney Transplantation: Models of Allograft Rejection

Article DOI: 10.3791/52163-v 16:15 min October 11th, 2014
October 11th, 2014

Capitoli

Riepilogo

Here, we present a protocol to study the immunology of rejection. The surgical model presented reports a short operating time and a concise technique. Depending on the donor-recipient strain combination, the transplanted kidney may develop acute cellular rejection or chronic allograft damage, defined by interstitial fibrosis and tubular atrophy.

Tags

Kidney Transplantation Mouse Model Allograft Rejection Acute Rejection Chronic Rejection MHC Mismatch Interstitial Fibrosis Tubular Atrophy Surgical Technique
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