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The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport
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Capitoli
- 00:05Titolo
- 02:10Cannulation of the Mesenteric Lymph Duct
- 05:56Cannulation of the Duodenum and Carotid Artery
- 10:14Results: Representative Mesenteric Lymph Flow Rate and Lipid and Drug Transport Data
- 12:22Conclusion
Here we describe a technique to cannulate the mesenteric lymph duct in rats which enables quantification of lipid and drug transport via the lymphatic system following intestinal delivery. The technique can be adapted to assess mesenteric lymph concentrations and/or transport of fluid, immune cells, peptides, proteins and lipophilic molecules.
