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Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
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JoVE Journal Medicina
Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

DOI:
10.3791/52402-v

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14:54 min

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November 29, 2015

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, , ,
1Bascom Palmer Eye Institute,University of Miami Miller School of Medicine, 2Departments of Neurology and Biomedical Engineering,University of Miami Miller School of Medicine, 3Shiley Eye Center,University of California, 4Department of Ophthalmology and Vision Science,Fudan University

Capitoli

  • 00:00Titolo
  • 02:54Apparatus
  • 05:51Surgical Approach
  • 06:22Femoral Vein Catheterization
  • 08:42Optic Nerve Exposure
  • 10:12Intravenous Injection of Erythosin B and Laser Irradiation
  • 12:37Risultati
  • 13:24Discussion

Summary

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The goal of this protocol is to photochemically induce ischemic injury to the posterior optic nerve in rat. This model is critical to studies of the pathophysiology of posterior ischemic optic neuropathy, and therapeutic approaches for this and other optic neuropathies, as well as of other CNS ischemic diseases.

Tags

Posterior Ischemic Optic NeuropathyPIONPhotochemically-induced ModelRat ModelErythrosin BLaserRetinal Ganglion CellsMicrovascular OcclusionIschemic InjuryOptic NeuropathiesCNS Ischemic Diseases

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