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评估传染性海绵状脑病物种界限与<em>在体外</em>朊蛋白转化测定法
JoVE Journal
Medicina
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JoVE Journal Medicina
Assessing Transmissible Spongiform Encephalopathy Species Barriers with an In Vitro Prion Protein Conversion Assay
DOI:

11:41 min

March 10, 2015

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Capitoli

  • 00:05Titolo
  • 01:41Preparation of Conversion Efficiency Ratio (CER) Assay Substrate Pairs
  • 05:30Preparation of Transmissible Spongiform Encephalopathy (TSE) Agent Seeds
  • 06:16Conversion Efficiency Ratio (CER) Assay
  • 09:19Results: Conversion of PrPc from Mouse Substrate to PrPres
  • 10:58Conclusion

Summary

Traduzione automatica

Measuring the barrier to the interspecies transmission of prion diseases is challenging and typically involves animal challenges or biochemical assays. Here, we present an in vitro prion protein conversion assay with the ability to predict species barriers.

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