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口咽念珠菌病的免疫缺陷小鼠Th17细胞炎症模型
JoVE Journal
Medicina
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JoVE Journal Medicina
Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice
DOI:

08:02 min

February 18, 2015

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Capitoli

  • 00:05Titolo
  • 01:19Reconstituting Rag1-deficient Mice with Th17 Cells
  • 02:57Harvesting C. albicans
  • 04:21Mice Infection
  • 06:16TREGs are Required with Th17 to Clear Candida Infections
  • 07:38Conclusion

Summary

Traduzione automatica

Although Candida infection models are available to study host immune resistance, a model to study T cell mediated immunopathology in the context of Candida infection is absent. Here we describe a method to establish Th17 immunopathology associated with oral Candida infection in immunodeficient mice.

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