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Utilizzando Murine inducibile telomerasi alleli in Studi di Tissue Degeneration / Regeneration e il cancro
JoVE Journal
Medicina
This content is Free Access.
JoVE Journal Medicina
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
DOI:

08:34 min

April 13, 2015

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Capitoli

  • 00:05Titolo
  • 01:35Reactivation of Telomerase in mTERT-ER and LSL-mTERT Mice In Vivo
  • 02:33Isolation of Neural Stem Cells and Reactivation of Telomerase In Vitro
  • 05:07Telomere FISH
  • 06:37Results: Effect of Telomerase Reactivation
  • 08:01Conclusion

Summary

Traduzione automatica

Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.

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