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JoVE Journal Medicine
Demonstration of the Rat Ischemic Skin Wound Model
 

Demonstration of the Rat Ischemic Skin Wound Model

Article DOI: 10.3791/52637-v • 08:35 min • April 1st, 2015
April 1st, 2015 •
*1, *1,2, 1, 2, 1,3
1Department of Molecular Pharmacology and Physiology, University of South Florida, 2Department of Surgery, University of South Florida, 3Wound Recovery and Hyperbaric Medicine Center, Kent Memorial Hospital
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

The rat, due to its size, availability, and rather docile behavior, has been utilized as a research model for many years. The goal of this protocol is to utilize the rat as an ischemic skin wound healing model to provide valuable insight into the pathophysiology of chronic wounds.

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Rat Ischemic Skin Wound Model Chronic Wounds Ageing Disease Conditions Diabetes Impaired Cardiovascular Function Unrelieved Pressure Animal Models Mimic Conditions Understanding Complexity Prolonged Reduction Of Blood Flow Ischemic Wounds Chronic Wound Phenotype Reduced Vascularization Increased Inflammation Delayed Wound Closure Bipedicled Dorsal Flap Controls Silicone Sheet Barrier And Splint Prevent Revascularization Reduce Contraction Debate Of Using Rats For Wound Healing Studies Anatomic And Physiologic Differences Panniculus Carnosus Muscle Short Life-span Hair Follicles
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