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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
 

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Article DOI: 10.3791/52978-v • 06:01 min • August 18th, 2015
August 18th, 2015 •
1, 1
1Department of Pediatrics, Division of Neurology, The Emory University School of Medicine

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Thromboembolic stroke models are vital tools for optimizing the recanalization therapy. Here we report a murine thrombotic stroke model based on transient cerebral hypoxic-ischemic (tHI) insult, which triggers thrombosis and infarction, and responds favorably to tissue plasminogen activator (tPA)-mediated fibrinolysis in a therapeutic window similar to those in stroke patients.

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Thrombotic Stroke Model Transient Cerebral Hypoxia-ischemia TPA Thrombolysis Preclinical Stroke Research Carotid Artery Occlusion Oxygen Delivery Rectal Temperature Maintenance Reperfusion Deficits Fibrin Deposition Platelet Deposition Infarct Size Reduction Mortality Rate Reduction Standardized Stroke Model
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