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Label-free Single Molecule Detection Using Microtoroid Optical Resonators
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JoVE Journal Bioingegneria
Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

DOI:
10.3791/53180-v

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08:53 min

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December 29, 2015

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1Division of Biology and Biological Engineering,California Institute of Technology

Capitoli

  • 00:05Titolo
  • 00:32Setup and Sample Preparation
  • 06:23Frequency Locking
  • 07:19Result: Changes in the Resonance Wavelength during Binding of Nanovesicles, Silica Beads, and Human Interleukin-2 Molecules
  • 08:28Conclusion

Summary

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Traduzione automatica

We have developed a label-free biosensing system based on optical resonator technology known as Frequency Locking Optical Whispering Evanescent Resonator (FLOWER) that is capable of detecting single molecules in solution. Here the procedures behind this work are described and presented.

Tags

Label-free Single Molecule DetectionMicrotoroid Optical ResonatorsFLOWER TechniqueLabel-free SensingSingle Molecule DetectionOptical ResonatorsEvanescent Field DetectionSignal-to-noise Ratio Improvement

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