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דגם bm12 העין מתנהל של זאבת אדמנתית המערכתית (לופוס) בC57BL עכברים / 6
JoVE Journal
Medicina
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JoVE Journal Medicina
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
DOI:

12:04 min

November 01, 2015

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Capitoli

  • 00:05Titolo
  • 00:54Final Tissue Harvest
  • 06:10Flow Cytometry Staining
  • 09:34Results: Characterization of T Cells, B Cells, and Plasma Cells in a Systemic Lupus Erythematosus Mouse Model
  • 11:36Conclusion

Summary

Traduzione automatica

The transfer of bm12 lymphocytes into a C57BL/6 recipient is an established model of systemic lupus erythematosus. Here we describe how to initiate disease using this model and how to characterize T follicular helper cells, germinal center B cells and plasma cells by flow cytometry.

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