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Bioengineering

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JoVE Journal Bioengineering
Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy
 

Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy

Article DOI: 10.3791/53447-v • 11:51 min • March 1st, 2016
March 1st, 2016 •
1, 2, 2, 1,3, 2, 1
1Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, 3Stem Cell & Regenerative Medicine Consortium, LKS Faculty of Medicine, University of Hong Kong

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This manuscript describes the creation of defined engineered cardiac tissues using surface marker expression and cell sorting. The defined tissues can then be used in a multi-tissue bioreactor to investigate mechanisms of cardiac cell therapy in order to provide a functional, yet controlled, model system of the human heart.

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Human Engineered Cardiac Tissues Cardiac Cell Therapy Cardiac Tissue Engineering Cellular Composition Variability Control Cardiac Differentiation Efficiencies Specific Cell Types Cardiac Contractile Function Therapy For Heart Disease Biomedic Screening Platform Therapeutic Interventions Mechanisms Of Cardiac Cell Therapy Human Embryonic Stem Cells Cardiomyocyte Cultures Trypsin-EDTA ROCK Inhibitor Trypsin Neutralization Solution
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