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干细胞基工程免疫抗HIV感染的人性化小鼠模型
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Medicina
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JoVE Journal Medicina
Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
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干细胞基工程免疫抗HIV感染的人性化小鼠模型

DOI:
10.3791/54048-v

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11:38 min

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July 02, 2016

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, , , , , , , ,
1David Geffen School of Medicine,University of California, Los Angeles

Capitoli

  • 00:05Titolo
  • 01:07Construction of Humanized Mice Engineered with CD4 Chimeric Antigen Receptor: Thymus Processing
  • 02:18Liver Processing
  • 05:18Tissue Transplantation to Construct Genetically Engineered Mice
  • 09:28Results: Characteristics of CD4 Chimeric Antigen Receptor Modified Cells
  • 10:39Conclusion

Summary

Traduzione automatica

Traduzione automatica

This protocol describes the methods in constructing a humanized bone-marrow/liver/thymus mouse model with stem cell-based engineered immunity against HIV infection.

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Keywords: Stem CellEngineered ImmunityHIV InfectionHumanized Mouse ModelChimeric Antigen ReceptorAnti-viral ImmunityAnti-tumor ImmunityBLT MiceCell-based Gene TherapyCD34+ HSCsFetal LiverCell Isolation

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