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보호 효능 및 폐 면역 반응은 마우스에 피하 및 비강 BCG 관리에 따라
JoVE Journal
Immunologia e infezioni
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JoVE Journal Immunologia e infezioni
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
DOI:

06:32 min

September 19, 2016

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Capitoli

  • 00:05Titolo
  • 00:55Mouse BCG Vaccination and Mycobacterium tuberculosis Challenge
  • 02:18Bronchoalveolar Lavage (BAL) Sample Acquisition
  • 04:11Results: Representative Vaccine-specific Pulmonary Immune Response Analyses
  • 05:46Conclusion

Summary

Traduzione automatica

We herein detail the methodology followed to compare protective efficacy and lung immune response induced by intranasal and subcutaneous immunization with BCG in mouse model. Our results show the benefits of pulmonary vaccination and suggest a role for IL17-mediated response in vaccine-induced protection.

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