Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Jessica Felton; Kunrong Cheng; Anan Said; Aaron C. Shang; Su Xu; Diana Vivian; Melissa Metry; James E. Polli; Jean-Pierre Raufman

doi:10.3791/54597

Rivista

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Medicina

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Brug Multi-fluorerede galdesyrer og In vivo Magnetic Resonance Imaging til måling Bile Acid Transport

JoVE Journal
Medicina

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JoVE Journal Medicina

Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport

Brug Multi-fluorerede galdesyrer og In vivo Magnetic Resonance Imaging til måling Bile Acid Transport

DOI:

10.3791/54597-v

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08:42 min

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November 27, 2016

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Jessica Felton, Kunrong Cheng, Anan Said, Aaron C. Shang, Su Xu, Diana Vivian, Melissa Metry, James E. Polli, Jean-Pierre Raufman⁶

¹Department of Surgery,University of Maryland School of Medicine, ²Department of Medicine,University of Maryland School of Medicine, ³Department of Radiology,University of Maryland School of Medicine, ⁴Food and Drug Administration, ⁵Department of Pharmaceutical Sciences,University of Maryland School of Pharmacy, ⁶VA Maryland Health Care System

Capitoli

00:05Titolo
00:59¹⁹F-Labeled Bile Acid Gavage, Organ Harvest and Bile Acid Measurement
04:02Live Animal Proton (¹H) and Fluorine (¹⁹F) Magnetic Resonance Imaging (MRI)
05:51Results: Representative Multi-fluorinated Bile Acid (MFBA) Measurement in the Mouse Gallbladder
07:51Conclusion

Summary

Traduzione automatica

Værktøjer til at diagnosticere galdesyre malabsorption og måle galdesyretransport in vivo er begrænsede. En innovativ tilgang med levende dyr beskrives der bruger kombineret proton ^(1H) plus fluor ^(19F) magnetisk resonans; denne hidtil ukendte metodik har translationel potentiale til at screene for galdesyre malabsorption i klinisk praksis.