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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

DOI:
10.3791/54751-v

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11:43 min

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December 30, 2016

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, , , , , , , , , , ,
1Department of Nuclear Medicine, Klinikum rechts der Isar,Technische Universität München, 2Department of Chemistry,Technische Universität München, 3GE Global Research, 4Zentralinstitut für Medizintechnik der Technischen Universität München (IMETUM),Technische Universität München, 5Institute for Biological and Medical Imaging (IBMI),Helmholtz Zentrum München, 6IDG Institute of Developmental Genetics,Helmholtz Zentrum München

Capitoli

  • 00:05Titolo
  • 01:11Hyperpolarization of [1-13C]Pyruvate
  • 03:47Cell Culture Preparation
  • 04:5113C Magnetic Resonance Spectroscopy
  • 06:1013C Magnetic Resonance Imaging
  • 09:20Results: Metabolic Exchange of [1-13C]Pyruvate to [1-13C]Lactate in Prostate Carcinoma (PC3) Cells
  • 10:40Conclusion

Summary

Traduzione automatica

Traduzione automatica

Dynamic nuclear polarization with subsequent sample dissolution has enabled real-time studies of metabolism in biological systems. Hyperpolarized [1-13C]pyruvate was used to study lactate dehydrogenase activity in a prostate carcinoma cell line in vitro.

Tags

Keywords: Hyperpolarized 13CMagnetic Resonance SpectroscopyMagnetic Resonance ImagingDynamic Nuclear PolarizationCarbon-13Metabolic ImagingCancer MetabolismMetabolic Tumor SubtypesTreatment Monitoring

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